Bovine Aldo-keto reductase family 1 member B1,AKR1B1 ELISA KIT

SKU: E2349Bo

Size:96 Tests-1 Kit

Background:Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). {ECO:0000250|UniProtKB:P15121}.

Research_area:

Applications:ELISA

Target_protein:AKR1B1

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.015ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P16116

MASS(Da):35919

GeneID:317748

Synonyms:AKR1B1

Gene names:AKR1B1

Standard solution:12.8ng/ml