Beta-Catenin Monoclonal Antibody(13C6)

SKU: BT-MCA1342

Size:100μL

Background:The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Research_area:Signal transduction; Neuroscience; Epigenetics and nuclear signaling; Cardiovascular; Cancer; Stem cells

Target_protein:CTNNB1

applications:WB, IHC-p, IF

Reactivity:Human,Mouse,Rat

Clonality:Monoclonal

Clone ID:

Host:Mouse

Isotype:IgG

Gene Symbol/ Name:Catenin beta-1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):85497

UniProt accession:Human: P35222; Mouse: Q02248; Rat: Q9WU82

Synonyms:CTNNB1; CTNNB; OK; SW-cl.35; Catenin beta-1; Beta-catenin

GeneID:Human: 1499; Mouse: 12387; Rat: 84353