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GeneBio Systems

ATRX Polyclonal Antibody

ATRX Polyclonal Antibody

E-AB-19609

£423.00 GBP
£423.00 GBP
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Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: ATRX

Target Synonym: Alpha thalassemia/mental retardation syndrome X linked homolog;ATP dependent helicase ATRX;ATP-dependent helicase ATRX;ATR2;Atrx;ATRX;DNA dependent ATPase and helicase;Helicase 2; X linked;MGC2094;MRXHF1;RAD54;RAD54L;SFM1;SHS;Transcriptional regulator ATRX;X linked helicase II;X linked nuclear protein;X-linked helicase II;X-linked nuclear protein;XH2;XNP;Znf HX;Znf-HX

Research Areas: Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P46100

Accession:

Background: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Concentration: 0.7 mg/mL

Immunogen: Synthetic peptide of human ATRX

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:30-1:150

Calculated MW:

ObservedMW:

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