ATG12 antibody , Cat. # FNab10376

SKU: FNab10376

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.

Immunogen:ATG12 autophagy related 12 homolog(S. cerevisiae)

Synonyms:APG12, APG12L

Observed MW:48-50kd

Uniprot ID:O94817

Reactivity:Human, Mouse

Tested Application:ELISA, IHC

Recommended dilution:IHC: 1:50-1:200

Gene ID:9140

Research Area:Epigenetics, Immunology, Cardiovascular, Metabolism