APLP-1 rabbit pAb

SKU: ES3788

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Mouse

Dilution:Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000. Not yet tested in other applications.

Immunogen:Synthesized peptide derived from APLP-1 . at AA range: 360-440

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):72kD

Human_gene_id:333

Human_swiss_prot_no:P51693

Subcellular_location:Cell membrane; Single-pass type I membrane protein.; [C30]: Cytoplasm. C-terminally processed in the Golgi complex.

Other_name:APLP1; Amyloid-like protein 1; APLP; APLP-1

Background:This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],