Anti-YKL-40/CHI3L1 Antibody Picoband®

SKU: A01283-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ICC,IF,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human; Mouse; Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: CHI3L1

Specificity:

Background: Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

Immunogen: E.coli-derived human YKL-40/CHI3L1 recombinant protein (Position: S103-T383).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Chung, C., Tallerico, T., Seeman, P. Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene. Synapse 50: 29-34, 2003. 2. Hakala, B. E., White, C., Recklies, A. D. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J. Biol. Chem. 268: 25803-25810, 1993. 3. Ober, C., Tan, Z., Sun, Y., Possick, J. D., Pan, L., Nicolae, R., Radford, S., Parry, R. R., Heinzmann, A., Deichmann, K. A., Lester, L. A., Gern, J. E., Lemanske, R. F., Jr., Nicolae, D. L., Elias, J. A., Chupp, G. L. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. New Eng. J. Med. 358: 1682-1691, 2008.

Uniprot ID: P36222

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 43 kDa

Calculated Molecular Weight:

Gene ID: 1116

Protein Name: Chitinase-3-like protein 1

Gene Full Name: chitinase 3 like 1

Synonyms: 39 kDa synovial protein; ASRT7; Cartilage glycoprotein 39; CGP 39; CHI3L1; CHI3L1/YKL40; Chitinase 3 like protein 1; Chitinase 3-like 1; GP 39; GP39; HC gp39; hCGP 39; HCGP 3P; YKL 40; YKL40; YYL 40