Anti-TTI2 Antibody Picoband®

SKU: A12943-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: TTI2

Specificity:

Background: TELO2 interacting protein 2 is a protein that in humans is encoded by the TTI2 gene. This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

Immunogen: E.coli-derived human TTI2 recombinant protein (Position: E80-T508).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/11/2012. 2. Hurov, K. E., Cotta-Ramusino, C., Elledge, S. J. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev. 24: 1939-1950, 2010. 3. Langouet, M., Saadi, A., Rieunier, G., Moutton, S., Siquier-Pernet, K., Fernet, M., Nitschke, P., Munnich, A., Stern, M.-H., Chaouch, M., Colleaux, L. Mutation in TTI2 reveals a role for triple T complex in human brain development. Hum. Mutat. 34: 1472-1476, 2013.

Uniprot ID: Q6NXR4

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 60 kDa

Calculated Molecular Weight:

Gene ID: 80185

Protein Name: TELO2-interacting protein 2

Gene Full Name: TELO2 interacting protein 2

Synonyms: C8orf41; TTI2