Anti-TIMM17A Antibody Picoband®

SKU: A12168-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: Flow Cytometry,IF,IHC,IHC-F,ICC,WB

Application Details: Western blot, 0.1-0.5μg/ml
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml
Immunohistochemistry (Frozen Section), 0.5-1μg/ml
Immunocytochemistry/Immunofluorescence, 2μg/ml
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells

Gene Name: TIMM17A

Specificity: No cross reactivity with other proteins.

Background: Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene. It is mapped to 1q32.1. TIM17 is a conserved suppressor of mtDNA instability, and overexpression of TIMM17A can prevent mtDNA loss in a human cellular model of mitochondrial disease.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TIMM17A, which shares 88.2% and 82.4% amino acid (aa) sequence identity with mouse and rat TIMM17A, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bauer, M. F., Gempel, K., Reichert, A. S., Rappold, G. A., Lichtner, P., Gerbitz, K. D., Neupert, W., Brunner, M., Hofmann, S. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J. Molec. Biol. 289: 69-82, 1999. 2. Bomer, U., Rassow, J., Zufall, N., Pfanner, N., Meijer, M., Maarse, A. C. The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. J. Molec. Biol. 262: 389-395, 1996. 3. Iacovino, M., Granycome, C., Sembongi, H., Bokori-Brown, M., Butow, R. A., Holt, I. J., Bateman, J. M. The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum. Molec. Genet. 18: 65-74, 2009.

Uniprot ID: Q99595

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 18 kDa

Calculated Molecular Weight:

Gene ID: 10440

Protein Name: Mitochondrial import inner membrane translocase subunit Tim17-A

Gene Full Name: translocase of inner mitochondrial membrane 17A

Synonyms: MIMT17; TIM17; TIM17A; TIMM17; TIMM17A