Anti-STAT1 Antibody Picoband®

SKU: PA1508

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: Flow Cytometry,WB

Application Details: Western blot, 0.1-0.5μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Gene Name: STAT1

Specificity: No cross reactivity with other proteins.

Background: Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human STAT1.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Deberry C, Mou S, Linnekin D (October 1997). Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem. J. 327 (1): 73–80. 2. Ouchi T, Lee SW, Ouchi M, Aaronson SA, Horvath CM (May 2000). Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5208–13. 3. Zhang JJ, Vinkemeier U, Gu W, Chakravarti D, Horvath CM, Darnell JE (Dec 1996). Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15092–6.

Uniprot ID: P42224

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 91 kDa

Calculated Molecular Weight: 87335 MW

Gene ID: 6772

Protein Name: Signal transducer and activator of transcription 1-alpha/beta

Gene Full Name: signal transducer and activator of transcription 1

Synonyms: ISGF 3; STAT1; STAT91