Anti-ST2/IL1RL1 Antibody Picoband®

SKU: A00492-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: IL1RL1

Specificity:

Background: Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.

Immunogen: E.coli-derived human ST2/IL1RL1 recombinant protein (Position: Q70-Q556).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Brint, E. K., Xu, D., Liu, H., Dunne, A., McKenzie, A. N. J., O'Neill, L. A. J., Liew, F. Y. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nature Immun. 5: 373-379, 2004. 2. Buckley, J. M., Liu, J. H., Li, C. H., Blankson, S., Wu, Q. D., Jiang, Y., Redmond, H. P., Wang, J. H. Increased susceptibility of ST2-deficient mice to polymicrobial sepsis is associated with an impaired bactericidal function. J. Immun. 187: 4293-4299, 2011. 3. Chackerian, A. A., Oldham, E. R., Murphy, E. E., Schmitz, J., Pflanz, S., Kastelein, R. A. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J. Immun. 179: 2551-2555, 2007.

Uniprot ID: Q01638

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 70 kDa

Calculated Molecular Weight: 29159 MW

Gene ID: 9173

Protein Name: Interleukin-1 receptor-like 1

Gene Full Name: interleukin 1 receptor like 1

Synonyms: DER4; FIT 1; IL1RL1; IL-1RL1; IL-33R; interleukin 1 receptor like 1; Protein ST2; ST2; ST2L; ST2V; T1; IL 1RL1