Anti-SPECC1L Antibody Picoband®

SKU: A09120-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SPECC1L

Specificity:

Background: This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

Immunogen: E.coli-derived human SPECC1L recombinant protein (Position: D177-E959).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Allanson, J. E. G syndrome: an unusual family. Am. J. Med. Genet. 31: 637-642, 1988. 2. Bhoj, E. J., Haye, D., Toutain, A., Bonneau, D., Nielsen, I. K., Lund, I. B., Bogaard, P., Leenskjold, S., Karaer, K., Wild, K. T., Grand, K. L., Astiazaran, M. C., and 16 others. Phenotypic spectrum associated with SPEC1L pathogenic variants: new families and critical review of the nosology of Teebi, Opitz GBBB, and Baraitser-Winter syndromes. Europ. J. Med. Genet. 62: 103588, 2019. 3. Bhoj, E. J., Li, D., Harr, M. H., Tian, L., Wang, T., Zhao, Y., Qiu, H., Kim, C., Hoffman, J. D., Hakonarson, H., Zackai, E. H. Expanding the SPECC1L mutation phenotypic spectrum to include Teebi hypertelorism syndrome. Am. J. Med. Genet. 167A: 2497-2502, 2015.

Uniprot ID: Q69YQ0

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 150 kDa

Calculated Molecular Weight: 124,544 MW

Gene ID: 23384

Protein Name: Cytospin-A

Gene Full Name: sperm antigen with calponin homology and coiled-coil domains 1 like

Synonyms: cytospin A; CYTSA; KIAA0376; SPECC1 like protein; SPECC1L