Anti-SMC3 Antibody Picoband® (monoclonal, 4C12)

SKU: M01930-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: IHC,WB

Application Details: Western blot, 0.1-0.5μg/ml
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml

Gene Name: SMC3

Specificity: No cross reactivity with other proteins.

Background: Structural maintenance of chromosomes 3, also known as SMC3, is a human gene. This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SMC3 , identical to the related mouse sequence.

Clonality: Monoclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: SMC3 structural maintenance of chromosomes 3. 2. Ghiselli G, Coffee N, Munnery CE, Koratkar R, Siracusa LD (2003). The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway.J. Biol. Chem. 278 (22): 20259–67. 3. Patel CA, Ghiselli G (2005). Hinderin, a five-domains protein including coiled-coil motifs that binds to SMC3. BMC Cell Biol. 6 (1): 3.

Uniprot ID: Q9UQE7

Host: Mouse

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Mouse IgG1

Phospho_site:

Clone Number: Clone: 4C12

Observed Molecular Weight: 142 kDa

Calculated Molecular Weight: 25035 MW

Gene ID: 9126

Protein Name: Structural maintenance of chromosomes protein 3

Gene Full Name: structural maintenance of chromosomes 3

Synonyms: BAM; Bamacan; BMH; CDLS3; CSPG6; HCAP; SMC 3; SMC protein 3; SMC3; SMC3L1