Anti-SLC26A4 Antibody Picoband®

SKU: A00919-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml

Gene Name: SLC26A4

Specificity: No cross reactivity with other proteins.

Background: Pendrin, is an anion exchange protein that in humans is encoded by the SLC26A4 gene. Pendrin is an ion exchanger found in many types of cells in the body. High levels of pendrin expression have been identified in the inner ear and thyroid. In the thyroid, pendrin mediates a component of the efflux of iodide across the apical membrane of the thyrocyte, which is critical for the formation of thyroid hormone. The exact function of pendrin in the inner ear remains unclear; however, pendrin may play a role in acid-base balance as a chloride-bicarbonate exchanger, regulate volume homeostasis through its ability to function as a chloride-formate exchanger or inly modulate the calcium concentration of the endolymph.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SLC26A4, which shares 84.4% amino acid (aa) sequence identity with both mouse and rat SCNN1A.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: SLC26A4 solute carrier family 26, member 4. 2. Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP (April 1999). The Pendred syndrome gene encodes a chloride-iodide transport protein. Nature Genetics. 21 (4): 440–3. 3. Wall SM (2006). The renal physiology of pendrin (SLC26A4) and its role in hypertension. Novartis Foundation Symposium. Novartis Foundation Symposia. 273: 231–9; discussion 239–43, 261–4.

Uniprot ID: O43511

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 86 kDa

Calculated Molecular Weight:

Gene ID: 5172

Protein Name: Pendrin

Gene Full Name: solute carrier family 26 member 4

Synonyms: solute carrier family 26 member 4; DFNB4; EVA; PDS; TDH2B; SLC26A4