Anti-SCNM1 Antibody Picoband®

SKU: A10999-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: SCNM1

Specificity:

Background: SCNM1 is a zinc finger protein and putative splicing factor. In mice, Scnm1 modifies phenotypic expression of Scn8a (MIM 600702) mutations.

Immunogen: E.coli-derived human SCNM1 recombinant protein (Position: D8-D230). Human SCNM1 shares 82.1% amino acid (aa) sequence identity with mouse SCNM1.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Buchner, D. A., Trudeau, M., Meisler, M. H. SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science 301: 967-969, 2003. 2. Howell, V. M., Jones, J. M., Bergren, S. K., Li, L., Billi, A. C., Avenarius, M. R., Meisler, M. H. Evidence for a direct role of the disease modifier SCNM1 in splicing. Hum. Molec. Genet. 16: 2506-2516, 2007. 3. Iturrate, A., Rivera-Barahona, A., Flores, C. L., Otaify, G. A., Elhossini, R., Perez-Sanz, M. L., Nevado, J., Tenorio-Castano, J., Trivino, J. C., Garcia-Gonzalo, F. R., Piceci-Sparascio, F., De Luca, A., Martinez, L., Kalayci, T., Lapunzina, P., Altunoglu, U., Aglan, M., Abdalla, E., Ruiz-Perez, V. L. Mutations in SCNM1 cause orofaciodigital syndrome due to minor intron splicing defects affecting primary cilia. Am. J. Hum. Genet. 109: 1828-1849, 2022.

Uniprot ID: Q9BWG6

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 26 kDa

Calculated Molecular Weight: 26 KDa

Gene ID: 79005

Protein Name: Sodium channel modifier 1

Gene Full Name: TNFAIP8L2-SCNM1 readthrough

Synonyms: SCNM1; Sodium channel modifier 1