Anti-RRBP1 Antibody Picoband®

SKU: A07074-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: ELISA,IF,IHC,ICC,WB,Flow Cytometry

Application Details: Western blot, 0.1-0.25 μg/ml, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg /1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: RRBP1

Specificity:

Background: Ribosome-binding protein 1, also referred to as p180, is a protein that in humans is encoded by the RRBP1 gene. It is mapped to 20p12.1. This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12.

Immunogen: E.coli-derived human RRBP1 recombinant protein (Position: Q1289-D1400).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Basson, C. T., MacRae, C. A., Schoenberg-Fejzo, M., Morton, C. C., Spinner, N. B., Genin, A., Krug, E., Seidman, J. G., Seidman, C. E. Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130. Genomics 35: 628-631, 1996. 2. Rezaee, M., Isokawa, K., Halligan, N., Markwald, R. R., Krug, E. L. Identification of an extracellular 130 kDa protein involved in early cardiac morphogenesis. J. Biol. Chem. 268: 14404-14411, 1993. 3. Basson CT, MacRae CA, Schoenberg-Fejzo M, Morton CC, Spinner NB, Genin A, Krug E, Seidman JG, Seidman CE (Dec 1996). Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130. Genomics. 35 (3): 628–31.

Uniprot ID: Q9P2E9

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 190-200 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 6238

Protein Name: Ribosome-binding protein 1

Gene Full Name: ribosome binding protein 1

Synonyms: 180 kDa ribosome receptor homolog; ES/130; ES/130 related protein; ES130; hES; KIAA1398; Ribosome binding protein 1; Ribosome receptor protein; RRBP1; RRp