Anti-RIM1/RIMS1 Antibody Picoband®

SKU: A05490

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: WB,IHC,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat
ELISA, 0.1-0.5 μg/ml

Gene Name: RIMS1

Specificity:

Background: The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene.

Immunogen: E.coli-derived human RIM1/RIMS1 recombinant protein (Position: K49-E1456).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Barragan, I., Marcos, I., Borrego, S., Antinolo, G. Molecular analysis of RIM1 in autosomal recessive retinitis pigmentosa. Ophthalmic Res. 37: 89-93, 2005. 2. Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J.-S., Scheuss, V., Rosenmund, C., Rettig, J., Brose, N. Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron 30: 183-196, 2001. 3. Castillo, P. E., Schoch, S., Schmitz, F., Sudhof, T. C., Malenka, R. C. RIM1-alpha is required for presynaptic long-term potentiation. Nature 415: 327-330, 2002.

Uniprot ID: Q86UR5,Q99NE5

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 189 kDa

Calculated Molecular Weight: 189 kDa

Gene ID: 22999116837

Protein Name: Aldehyde dehydrogenase 1 family member A3

Gene Full Name: regulating synaptic membrane exocytosis 1

Synonyms: CORD7, KIAA0340, Rab 3 interacting molecule 1, Rab 3 interacting protein 2, RAB3IP2, RIM, RIM 1, RIM1, RIMS1