Anti-P-Cadherin-3 CDH3-Antibody (Monoclonal, CH-19)

SKU: MA1079

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Chicken,Human,Mouse,Rabbit,Rat,Snake

Applications: IHC,WB

Application Details: Immunohistochemistry (Paraffin-embedded Section), 2-4μg/ml, Human, mouse, rat, rabbit, chicken, snake.
Western blot, 1-2μg/ml, Human, mouse, rat, rabbit, chicken, snake.

Gene Name: CDH1; CDH2; CDH3

Specificity: No cross reactivity with other proteins.

Background: Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are though to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma.

Immunogen: Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled to KLH.

Clonality: Monoclonal

Contents: Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3. *This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Ascites

Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Reference: 1. Togashi, H.; Abe, K.; Mizoguchi, A.; Takaoka, K.; Chisaka, O.; Takeichi, M. : Cadherin regulates dendritic spine morphogenesis. Neuron 35: 77-89, 2002. 2. Chalmers, I. J.; Hofler, H.; Atkinson, M. J. : Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. Genomics 57: 160-163, 1999.

Uniprot ID: F1LMI3

Host: Mouse

Concentration: Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Mouse IgG1

Phospho_site:

Clone Number: Clone: CH-19

Observed Molecular Weight: 53 kDa

Calculated Molecular Weight: 90415 MW

Gene ID: Human(999), Mouse(12550), Rat(83502), Human(1000), Mouse(12558), Rat(83501), Human(1001), Mouse(12560), Rat(116777)

Protein Name: Cadherin 3

Gene Full Name: cadherin 3

Synonyms: Cadherin 3; CDH3; CDHP; HJMD; PCAD; P-cadherin