Anti-OMA1 Antibody Picoband®

SKU: A06260

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,ICC/IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml

Gene Name: OMA1

Specificity:

Background: Enables metalloendopeptidase activity. Involved in several processes, including HRI-mediated signaling; proteolysis; and regulation of mitochondrion organization. Located in mitochondrial inner membrane. Is active in mitochondrial intermembrane space.

Immunogen: E.coli-derived human OMA1 recombinant protein (Position: K256-H483). Human OMA1 shares 83.3% amino acid (aa) sequence identity with both mouse and rat OMA1.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bao, Y.-C., Tsuruga, H., Hirai, M., Yasuda, K., Yokoi, N., Kitamura, T., Kumagai, H. Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif. DNA Res. 10: 123-128, 2003. 2. Fessler, E., Eckl, E.-M., Schmitt, S., Mancilla, I. A., Meyer-Bender, M. F., Hanf, M., Philippou-Massier, J., Krebs, S., Zischka, H., Jae, L. T. A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol. Nature 579: 433-437, 2020. 3. Guo, X., Aviles, G., Liu, Y., Tian, R., Unger, B. A., Lin, Y.-H. T., Wiita, A. P., Xu, K., Correia, M. A., Kampmann, M. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature 579: 427-432, 2020.

Uniprot ID: Q96E52

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 60 kDa

Calculated Molecular Weight: 60 kDa

Gene ID: 115209

Protein Name: Metalloendopeptidase OMA1, mitochondrial

Gene Full Name: OMA1 zinc metallopeptidase

Synonyms: 2010001O09Rik, DAB1, MPRP 1, MPRP1, OMA1, YKR087C, ZMPOMA1