Anti-NMU Antibody Picoband®

SKU: A01919-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: WB,IHC

Application Details: Western blot, 0.1-0.5μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Mouse, Rat

Gene Name: NMU

Specificity: No cross reactivity with other proteins.

Background: Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle, which was isolated first from porcine spinal cord and later from other species. It is a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human NMU, which shares 64% and 56% amino acid (aa) sequence identity with mouse and rat NMU, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Austin, C., Lo, G., Nandha, K. A., Meleagros, L., Bloom, S. R. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. J. Molec. Endocr. 14: 157-169, 1995. 2. Howard, A. D., Wang, R., Pong, S.-S., Mellin, T. N., Strack, A., Guan, X.-M., Zeng, Z., Williams, D. L., Jr., Feighner, S. D., Nunes, C. N., Murphy, B., Stair, J. N., and 13 others. Identification of receptors for neuromedin U and its role in feeding. Nature 406: 70-74, 2000.

Uniprot ID: P48645

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 26 kDa

Calculated Molecular Weight:

Gene ID: 10874

Protein Name: Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

Gene Full Name: neuromedin U

Synonyms: neuromedin U; NMU; Neuromedin-U-25; NmU-25