Anti-MSTO1 Antibody Picoband®

SKU: A13028-1

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,IHC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human
Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml

Gene Name: MSTO1

Specificity:

Background: Involved in mitochondrion distribution; mitochondrion organization; and positive regulation of mitochondrial fusion. Located in mitochondrial outer membrane. Is active in cytosol.

Immunogen: E.coli-derived human MSTO1 recombinant protein (Position: E44-Q518). Human MSTO1 shares 78.1% amino acid (aa) sequence identity with mouse MSTO1.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Donkervoort, S., Sabouny, R., Yun, P., Gauquelin, L., Chao, K. R., Hu, Y., Al Khatib, I., Topf, A., Mohassel, P., Cummings, B. B., Kaur, R., Saade, D., and 37 others. MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement. Acta Neuropath. 138: 1013-1031, 2019. 2. Gal, A., Balicza, P., Weaver, D., Naghdi, S., Joseph, S. K., Varnai, P., Gyuris, T., Horvath, A., Nagy, L., Seifert, E. L., Molnar, J. J., Hajnoczky, G. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans. EMBO Molec. Med. 9: 967-984, 2017. Note: Erratum: 15: e17911, 2023. 3. Gal, A., Balicza, P., Weaver, D., Naghdi, S., Joseph, S. K., Varnai, P., Gyuris, T., Horvath, A., Nagy, L., Seifert, E. L., Molnar, M. J., Hajnoczky, G. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans. EMBO Molec. Med. 15: e17911, 2023. Note: Erratum.

Uniprot ID: Q9BUK6

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 62 kDa

Calculated Molecular Weight: 62 kDa

Gene ID: 55154

Protein Name: Protein misato homolog 1

Gene Full Name: misato mitochondrial distribution and morphology regulator 1

Synonyms: MSTO1; LST005; SLTP005; Protein misato homolog 1