Anti-MFSD12 Antibody Picoband®

SKU: A16855-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,IHC,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: MFSD12

Specificity:

Background: The major facilitator superfamily consists of presumed carbohydrate transporters with 10-12 membrane-spanning domains. MFSD12 (major facilitator superfamily domain containing 12), also known as PP3501 or C19orf28, is a 480 amino acid multi-pass membrane protein that belongs to the major facilitator superfamily. Existing as two alternatively spliced isoforms, MFSD12 is encoded by a gene that maps to human chromosome 19p13.3. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families, and Fc receptors (FcRs).

Immunogen: E.coli-derived human MFSD12 recombinant protein (Position: Q66-H443). Human MFSD12 shares 86.8% amino acid (aa) sequence identity with mouse MFSD12.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Crawford, N. G., Kelly, D. E., Hansen, M. E. B., Beltrame, M. H., Fan, S., Bowman, S. L., Jewett, E., Ranciaro, A., Thompson, S., Lo, Y., Pfeifer, S. P., Jensen, J. D., and 36 others. Loci associated with skin pigmentation identified in African populations. Science 358: eaan8433, 2017. Note: Electronic Article. Erratum: Science 367: eaba7178, 2020. 2. Gross, M. B. Personal Communication. Baltimore, Md. 10/26/2017. 3. Hedan, B., Cadieu, E., Botherel, N., Dufaure de Citres, C., Letko, A., Rimbault, M., Drogemuller, C., Jagannathan, V., Derrien, T., Schmutz, S., Leeb, T., Andre, C. Identification of a missense variant in MFSD12 involved in dilution of phaeomelanin leading to white or cream coat color in dogs. Genes (Basel) 10: E386, 2019. Note: Electronic Article.

Uniprot ID: Q6NUT3

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 52 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 126321

Protein Name: Major facilitator superfamily domain-containing protein 12

Gene Full Name: major facilitator superfamily domain containing 12

Synonyms: MFSD12; C19orf28; Major facilitator superfamily domain-containing protein 12