Anti-LRRC73 Antibody Picoband®

SKU: A18460-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: LRRC73

Specificity:

Background: Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson’s disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The LRRC73 gene product has been provisionally designated LRRC73 pending further characterization.

Immunogen: E.coli-derived human LRRC73 recombinant protein (Position: M1-Q249).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Sakai, Y. , Shaw, C. A. , Dawson, B. C. , Dugas, D. V. , Al-Mohtaseb, Z. , & Hill, D. E. , et al. (2011). Protein interactome reveals converging molecular pathways among autism disorders. Science Translational Medicine, 3(86), 86ra49. 2. The dna sequence and analysis of human chromosome 6. Nature. 3. Capalbo, L. , Bassi, Z. I. , Geymonat, M. , Todesca, S. , Copoiu, L. , & Enright, A. J. , et al. The midbody interactome reveals unexpected roles for pp1 phosphatases in cytokinesis. Nature Communications.

Uniprot ID: Q5JTD7

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 42 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 221424

Protein Name: Leucine-rich repeat-containing protein 73

Gene Full Name: leucine rich repeat containing 73

Synonyms: LRRC73; C6orf154; Leucine-rich repeat-containing protein 73