Anti-KMO Antibody Picoband®

SKU: A05469-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse,Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human, Mouse
ELISA, 0.1-0.5 μg/ml, -

Gene Name: KMO

Specificity:

Background: Kynurenine 3-monooxygenase is an enzyme that in humans is encoded by the KMO gene. This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease.

Immunogen: E.coli-derived human KMO recombinant protein (Position: F26-N372).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Alberati-Giani, D., Cesura, A. M., Broger, C., Warren, W. D., Rover, S., Malherbe, P. Cloning and functional expression of human kynurenine 3-monooxygenase. FEBS Lett. 410: 407-412, 1997. 、 2. Giorgini, F., Guidetti, P., Nguyen, Q., Bennett, S. C., Muchowski, P. J. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nature Genet. 37: 526-536, 2005. 3. Halford, S., Freedman, M. S., Bellingham, J., Inglis, S. L., Poopalasundaram, S., Soni, B. G., Foster, R. G., Hunt, D. M. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. Genomics 72: 203-208, 2001.

Uniprot ID: O15229

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50 kDa

Calculated Molecular Weight: 39411 MW

Gene ID: 8564

Protein Name: Kynurenine 3-monooxygenase

Gene Full Name: kynurenine 3-monooxygenase

Synonyms: KMO; Kynurenine 3 hydroxylase; Kynurenine 3 monooxygenase