Anti-ITPRIPL1 Antibody Picoband®

SKU: A17509-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: ITPRIPL1

Specificity:

Background: ITPRIPL1 (inositol 1,4,5-triphosphate receptor-interacting protein-like 1), also known as KIAA1754L, is a 555 amino acid protein belonging to the ITPRIP family. ITPRIPL1 is a single-pass type I membrane protein expressed as two isoforms produced by alternative splicing events. The gene that encodes ITPRIPL1 maps to human chromosome 2, the second largest human chromosome, consisting of 237 million bases encoding over 1,400 genes and making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr?m syndrome is due to mutations in the ALMS1 gene. It has been hypothesized that human chromosome 2 is the result of an ancient fusion of two ancestral chromosome due to its composition of a vestigial second centromere and vestigial telomeres.

Immunogen: E.coli-derived human ITPRIPL1 recombinant protein (Position: Q165-H548). Human ITPRIPL1 shares 88.8% and 89% amino acid (aa) sequence identity with mouse and rat ITPRIPL1, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Lim, J., Hao, T., Shaw, C., Patel, A. J., Szabó, G., Rual, J. F., ... & Zoghbi, H. Y. (2006). A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell, 125(4), 801-814. 2. Khanna, R., Krishnamoorthy, V., & Parnaik, V. K. (2018). E3 ubiquitin ligase RNF 123 targets lamin B1 and lamin‐binding proteins. The FEBS Journal, 285(12), 2243-2262. 3. Zhang, Y., Shang, L., Zhang, J., Liu, Y., Jin, C., Zhao, Y., ... & Wang, J. (2022). An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Cell Chemical Biology, 29(1), 5-18.

Uniprot ID: Q6GPH6

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 70 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 150771

Protein Name: Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

Gene Full Name: ITPRIP like 1

Synonyms: ITPRIPL1; KIAA1754L; Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1