Anti-Integrin alpha 1/ITGA1 Antibody Picoband®

SKU: PA1045-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: IHC,WB

Application Details: Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Gene Name: ITGA1

Specificity: No cross reactivity with other proteins.

Background: Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1, different from the related mouse and rat sequences by one amino acid.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Douville, P.; Seldin, M. F.; Carbonetto, S. : Genetic mapping of the integrin alpha-1 gene (Vla1) to mouse chromosome 13. Genomics 14: 503-505, 1992. 2. Lee HJ, Kim SY; Koh JM; Bok J; Kim KJ; Kim KS; Park MH; Shin HD; Park BL; Kim TH; Hong JM; Park EK; Kim DJ; Oh B; Kimm K; Kim GS; Lee JY. Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral absorbance and fracture risk in postmenopausal Koreans.Bone. 2007 Dec;41(6):979-86. Epub 2007 Sep 5. 3. Ekholm, E.; Hankenson, K. D.; Uusitalo, H.; Hiltunen, A.; Gardner, H.; Heino, J.; Penttinen, R. : Diminished callus size and cartilage synthesis in alpha-1 beta-1 integrin-deficient mice during bone fracture healing. Am. J. Path. 160: 1779-1785, 2002.

Uniprot ID: P56199

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 190-200 kDa

Calculated Molecular Weight: 130848 MW

Gene ID: 3672

Protein Name: Integrin alpha-1

Gene Full Name: integrin subunit alpha 1

Synonyms: CD49a; Integrin alpha 1; integrin; alpha 1; ITGA1; VLA 1; VLA1