Anti-IL1RA Antibody (monoclonal, 12C13)

SKU: M00651-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Rat

Applications: ELISA (Cap)

Application Details: ELISA (Cap), 1-5μg/ml, Rat

Gene Name: Il1rn

Specificity:

Background: The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Immunogen: E. coli-derived rat IL1RA recombinant protein (Position: H27-Q178). Rat IL1RA shares 77.6% and 90.7% amino acid (aa) sequence identity with human and mouse IL1RA, respectively.

Clonality: Monoclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Entrez Gene: IL1RN interleukin 1 receptor antagonist. 2. Patterson D, Jones C, Hart I, Bleskan J, Berger R, Geyer D, Eisenberg SP, Smith MF, Arend WP (January 1993). The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region. Genomics. 15 (1): 173–6. 3. Steinkasserer A, Spurr NK, Cox S, Jeggo P, Sim RB (July 1992). The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics. 13(3): 654–7.

Uniprot ID: P25086

Host: Mouse

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Mouse IgG2b

Phospho_site:

Clone Number: Clone: 12C13

Observed Molecular Weight: 100-110 kDa

Calculated Molecular Weight:

Gene ID: 60582

Protein Name: Interleukin-1 receptor antagonist protein

Gene Full Name: interleukin 1 receptor antagonist

Synonyms: Anakinra; ICIL 1RA; IL 1ra; IL 1ra3; IL 1RN; IL1 inhibitor; IL1F3; IL1RA; IL-1RA; IL1RN; IRAP; IL-1RN