Anti-IFN gamma Receptor beta/AF-1/IFNGR2 Antibody Picoband®

SKU: A03158-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Mouse

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Mouse
ELISA, 0.1-0.5μg/ml, -

Gene Name: IFNGR2

Specificity: No cross reactivity with other proteins.

Background: Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the IFNGR2 gene. It is mapped to 16 C3.3; 16 53.07 cM. This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.

Immunogen: E.coli-derived mouse IFN gamma Receptor beta/AF-1/IFNGR2 recombinant protein (Position: A20-P332).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Bono, M. R., Alcaide-Loridan, C., Couillin, P., Letouze, B., Grisard, M. C., Jouin, H., Fellous, M. Human chromosome 16 encodes a factor involved in induction of class II major histocompatibility antigens by interferon gamma. Proc. Nat. Acad. Sci. 88: 6077-6081, 1991. 2. Bono, R., Hatat, D., Couillin, P., Grisard, M. C., Van Cong, N., Fisher, D., Fellous, M. Receptor for human gamma interferon is specified by human chromosomes 6 and 21. (Abstract) Cytogenet. Cell Genet. 46: 584, 1987. 3. Dorman, S. E., Holland, S. M. Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J. Clin. Invest. 101: 2364-2369, 1998.

Uniprot ID: Q63953

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 55 kDa

Calculated Molecular Weight: 65411 MW

Gene ID: 15980

Protein Name: Ifngr2 protein

Gene Full Name: interferon gamma receptor 2

Synonyms: AF 1; IFGR2; IFN gamma R2; IFN gamma receptor 2; IFNGR2; IFNGT1; Interferon gamma receptor 2; Interferon gamma transducer 1