Anti-HDDC2 Antibody Picoband®

SKU: A08033-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: HDDC2

Specificity:

Background: HDDC2 (HD Domain Containing 2) is located on human chromosome 6q22.31. The HDDC2 protein is ubiquitously expressed in adrenal, brain and other tissues. Structurally, the encoded protein is reported to be 27160 Da in mass. The HDDC2 (also known as C6orf74; CGI-130; NS5ATP2; dJ167O5.2) gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, rice, frog, etc. 239 organisms have orthologs with human gene HDDC2. HDDC2 catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).

Immunogen: E.coli-derived human HDDC2 recombinant protein (Position: A7-S204). Human HDDC2 shares 89.2% amino acid (aa) sequence identity with mouse HDDC2.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Lai, C. H., Chou, C. Y., Ch'ang, L. Y., Liu, C. S., & Lin, W. C. (2000). Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome research, 10(5), 703-713. 2. Seo, G., Han, H., Vargas, R. E., Yang, B., Li, X., & Wang, W. (2020). MAP4K interactome reveals STRN4 as a key STRIPAK complex component in hippo pathway regulation. Cell reports, 32(1). 3. Ulbrich, S., Janning, P., Seidel, R., Matschke, J., Gonsberg, A., Jung, S., ... & Tatzelt, J. (2018). Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer’s disease. PLoS one, 13(5), e0197659.

Uniprot ID: Q7Z4H3

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 26 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 51020

Protein Name: 5'-deoxynucleotidase HDDC2

Gene Full Name: HD domain containing 2

Synonyms: C6orf74; CGI 130; dJ167O5.2; HD domain containing 2; HD domain containing protein 2; HDDC2; NS5ATP2