Anti-GPCR LGR8/RXFP2 Antibody Picoband®

SKU: A04848-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: Flow Cytometry,WB

Application Details: Western blot, 0.1-0.5μg/ml
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells

Gene Name: RXFP2

Specificity: No cross reactivity with other proteins.

Background: Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human G-protein coupled receptor. It is mapped to 13q13.1. This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human GPCR LGR8.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Ars, E., Lo Giacco, D., Bassas, L., Nuti, F., Rajmil, O., Ruiz, P., Garat, J. M., Ruiz-Castane, E., Krausz, C. Further insights into the role of T222P variant of RXFP2 in non-syndromic cryptorchidism in two Mediterranean populations. Int. J. Androl. 34: 333-338, 2010. 2. Ferlin, A., Simonato, M., Bartoloni, L., Rizzo, G., Bettella, A., Dottorini, T., Dallapiccola, B., Foresta, C. The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. J. Clin. Endocr. Metab. 88: 4273-4279, 2003. 3. Harris, R. M., Finlayson, C., Weiss, J., Fisher, L., Hurley, L., Barrett, T., Emge, D., Bathgate, R. A. D., Agoulnik, A. I., Jameson, J. L. A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism. Mammalian Genome 21: 442-449, 2010.

Uniprot ID: Q8WXD0

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 86 kDa

Calculated Molecular Weight: 35883 MW

Gene ID: 122042

Protein Name: Relaxin receptor 2

Gene Full Name: relaxin family peptide receptor 2

Synonyms: relaxin family peptide receptor 2; GPR106; GREAT; INSL3R; LGR8; LGR8.1; RXFPR2; RXFP2