Anti-GGN Antibody Picoband®

SKU: A10914-2

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,Flow Cytometry

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Gene Name: GGN

Specificity:

Background: This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human GGN. Human GGN shares 93.8% amino acid (aa) sequence identity with both mouse and rat GGN.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Celse, T., Cazin, C., Mietton, F., Martinez, G., Martinez, D., Thierry-Mieg, N., Septier, A., Guillemain, C., Beurois, J., Clergeau, A., Mustapha, S. F. B., Kharouf, M., and 31 others. Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player. Hum. Genet. 140: 43-57, 2021. 2. Jamsai, D., Bianco, D. M., Smith, S. J., Merriner, D. J., Ly-Huynh, J. D., Herlihy, A., Niranjan, B., Gibbs, G. M., O'Bryan, M. K. Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail. Reproduction 135: 751-759, 2008. 3. Jamsai, D., Sarraj, M. A., Merriner, D. J., Drummond, A. E., Jones, K. T., McLachlan, R. I., O'Bryan, M. K. GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population. Int. J. Androl. 34: 624-632, 2011.

Uniprot ID: Q86UU5

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 67 kDa

Calculated Molecular Weight: 67 kDa

Gene ID: 199720

Protein Name: Gametogenetin

Gene Full Name: gametogenetin

Synonyms: GGN; Gametogenetin