Anti-GART Antibody Picoband®

SKU: A06061-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: GART

Specificity:

Background: Trifunctional purine biosynthetic protein adenosine-3 is an enzyme that in humans is encoded by the GART gene. The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Immunogen: E.coli-derived human GART recombinant protein (Position: E68-E1010). Human GART shares 86.2% amino acid (aa) sequence identity with mouse GART.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Brodsky, G., Barnes, T., Bleskan, J., Becker, L., Cox, M., Patterson, D. The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome. Hum. Molec. Genet. 6: 2043-2050, 1997. 2. Chadefaux, B., Allard, D., Rethore, M. O., Raoul, O., Poissonnier, M., Gilgenkrantz, S., Cheruy, C., Jerome, H. Assignment of human phosphoribosylglycinamide synthetase locus to region 21q221. Hum. Genet. 66: 190-192, 1984. 3. Cox, D. R., Goldblatt, D., Epstein, C. J. Chromosomal assignment of mouse PRGS: further evidence for homology between mouse chromosome 16 and human chromosome 21. (Abstract) Am. J. Hum. Genet. 33: 145A only, 1981.

Uniprot ID: P22102

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 108 kDa

Calculated Molecular Weight:

Gene ID: 2618

Protein Name: Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

Gene Full Name: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Synonyms: AIR synthase; AIRS; GAR transformylase; GARS; GART; GARTF; PAIS; PGFT; PRGS