Anti-FKBP1A/1B Antibody Picoband®

SKU: A04492-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: FKBP1A/1B

Specificity:

Background: Peptidyl-prolyl cis-trans isomerase FKBP1A/1B is an enzyme that in humans is encoded by the FKBP1A/1B gene. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

Immunogen: E.coli-derived human FKBP1A/1B recombinant protein (Position: M1-H88).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Aylett, C. H. S., Sauer, E., Imseng, S., Boehringer, D., Hall, M. N., Ban, N., Maier, T. Architecture of human mTOR complex 1. Science 351: 48-52, 2016. 2. DiLella, A. G., Hawkins, A., Craig, R. J., Schreiber, S. L., Griffin, C. A. Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. Biochem. Biophys. Res. Commun. 189: 819-823, 1992. 3. DiLella, A. G. Chromosomal assignment of the human immunophilin FKBP-12 gene. Biochem. Biophys. Res. Commun. 179: 1427-1433, 1991.

Uniprot ID: P62942/P68106

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 15 kDa

Calculated Molecular Weight: 54590 MW

Gene ID: 2280/2281

Protein Name: Kisspeptin

Gene Full Name: FKBP prolyl isomerase 1A/B

Synonyms: 12 kDa FK506 binding protein; 12 kDa FKBP; FK506 binding protein 1A; FKBP 12; FKBP 1A; FKBP1; FKBP12; FKBP12C; FKBP1A; Immunophilin FKBP12; PKC12; PKCI2; PPIASE; PPIase FKBP1A; Rotamase; 12.6 kDa FK506 binding protein; 12.6 kDa FKBP; FK506 binding protein 1B; FKBP 12.6; FKBP 1B; FKBP12.6; FKBP1B; FKBP1L; FKBP9; h FKBP 12; Immunophilin FKBP12.6; OTK4; PKBP1L; PPIase; PPIase FKBP1B; Rotamase