Anti-DNAJC3 Antibody Picoband®

SKU: A04805-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: DNAJC3

Specificity:

Background: DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene. This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).

Immunogen: E.coli-derived human DNAJC3 recombinant protein (Position: V33-E429).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Barber, G. N., Wambach, M., Thompson, S., Jagus, R., Katze, M. G. Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation. Molec. Cell. Biol. 15: 3138-3146, 1995. 2. Bublitz, S. K., Alhaddad, B., Synofzik, M., Kuhl, V., Lindner, A., Freiberg, C., Schmidt, H., Strom, T. M., Haack, T. B., Deschauer, M. Expanding the phenotype of DNAJC3 mutations: a case with hypothyroidism additionally to diabetes mellitus and multisystemic neurodegeneration. (Letter) Clin. Genet. 92: 561-562, 2017. 3. Gale, M., Jr., Blakely, C. M., Hopkins, D. A., Melville, M. W., Wambach, M., Romano, P. R., Katze, M. G. Regulation of interferon-induced protein kinase PKR: modulation of P58(IPK) inhibitory function by a novel protein, P52(rIPK). Molec. Cell. Biol. 18: 859-871, 1998.

Uniprot ID: Q13217

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 58 kDa

Calculated Molecular Weight:

Gene ID: 5611

Protein Name: DnaJ homolog subfamily C member 3

Gene Full Name: DnaJ heat shock protein family (Hsp40) member C3

Synonyms: DNAJC3; HP58; P58; P58IPK; PRKRI; Protein kinase inhibitor p58