Anti-c-Rel/REL Antibody Picoband®

SKU: A01880-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: REL

Specificity:

Background: The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen: E.coli-derived human c-Rel/REL recombinant protein (Position: K116-D610).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Beaussant-Cohen, S., Jaber, F., Massaad, M. J., Weeks, S., Jones, J., Alosaimi, M. F., Wallace, J., Al-Herz, W., Geha, R. S., Chou, J. Combined immunodeficiency in a patient with c-Rel deficiency. J. Allergy Clin. Immun. 144: 606-608, 2019. 2. Belguise, K., Sonenshein, G. E. PKC-theta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor-alpha synthesis. J. Clin. Invest. 117: 4009-4021, 2007. 3. Brownell, E., Fell, H. P., Tucker, P. W., Geurts van Kessel, A. H., Hagemeijer, A., Rice, N. R. Regional localization of the human c-rel locus using translocation chromosome analysis. Oncogene 2: 527-529, 1988.

Uniprot ID: Q04864

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 78 kDa

Calculated Molecular Weight:

Gene ID: 5966

Protein Name: Proto-oncogene c-Rel

Gene Full Name: REL proto-oncogene, NF-kB subunit

Synonyms: C Rel; Proto oncogene c Rel; REL