Anti-c-Maf/MAF Antibody Picoband®

SKU: A00654-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: ICC/IF,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human

Gene Name: MAF

Specificity: No cross reactivity with other proteins.

Background: Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene. It is mapped to 16q23.2. The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human c-Maf/MAF, identical to the related mouse and rat sequences.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (Oct 1989). v-maf, a viral oncogene that encodes a leucine zipper motif. Proceedings of the National Academy of Sciences of the United States of America. 86 (20): 7711–5. 2. Olbrot M, Rud J, Moss LG, Sharma A (May 2002). Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proceedings of the National Academy of Sciences of the United States of America. 99 (10): 6737–42. 3. Melloul D, Marshak S, Cerasi E (Mar 2002). Regulation of insulin gene transcription. Diabetologia. 45 (3): 309–26.

Uniprot ID: O75444

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 52 kDa

Calculated Molecular Weight: 39 kDa

Gene ID: 4094

Protein Name: Transcription factor Maf

Gene Full Name: MAF bZIP transcription factor

Synonyms: c MAF; cMAF; MAF; Proto oncogene c Maf; Transcription factor Maf