Anti-Batf2 Antibody Picoband®

SKU: A09891-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: WB,IHC,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: Batf2

Specificity:

Background: Basic leucine zipper transcription factor, ATF-like 2 is a protein that, in humans, is encoded by the BATF2 gene. BATF2 (basic leucine zipper transcription factor, ATF-like 2) is a 274 amino acid protein that localizes to the nucleus and contains one bZIP domain, suggesting that it may be involved in transcriptional regulation. The gene encoding BATF2, which is expressed as multiple alternatively spliced isoforms, is located on human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms’ tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-LemliOpitz syndrome are also associated with defects in chromosome 11-encoded genes.

Immunogen: E.coli-derived mouse Batf2 recombinant protein (Position: M1-L138).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Dash, R., Su, Z.-Z., Lee, S.-G., Azab, B., Boukerche, H., Sarkar, D., Fisher, P. B. Inhibition of AP-1 by SARI negatively regulates transformation progression mediated by CCN1. Oncogene 29: 4412-4423, 2010. 2. Huang, Q., Yang, Y., Li, X., Huang, S. Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL in human leukemia cells. Tumour Biol. 32: 1191-1197, 2011. 3. Su, Z.-z, Lee, S.-G., Emdad, L., Lebdeva, I. V., Gupta, P., Valerie, K., Sarkar, D., Fisher, P. B. Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). Proc. Nat. Acad. Sci. 105: 20906-20911, 2008.

Uniprot ID: Q8R1H8

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 25 kDa

Calculated Molecular Weight:

Gene ID: 74481

Protein Name: Basic leucine zipper transcriptional factor ATF-like 2

Gene Full Name: basic leucine zipper transcription factor, ATF-like 2

Synonyms: B ATF 2; BATF2; B-ATF-2