Anti-APC Monoclonal Antibody

SKU: M00008

Size: 100 μl

Storage: Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Form: Liquid

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,ICC,IF,IP

Application Details: WB 1:500-2000
IHC 1:50-200
ICC/IF 1:50-200
IP 1:20

Gene Name: APC

Specificity:

Background:

Immunogen: A synthesized peptide derived from human APC Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF) -induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Clonality: Monoclonal

Contents: Rabbit IgG in stabilizing components, phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
*This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Affinity-chromatography

Reconstitution:

Reference:

Uniprot ID: P25054

Host: Rabbit

Concentration: 0.5mg/ml

Conjugate:

Cross Reactivity:

Isotype: Rabbit IgG

Phospho_site:

Clone Number: Clone: FAD-1

Observed Molecular Weight: 160 kDa

Calculated Molecular Weight: 312 kDa

Gene ID: 324

Protein Name: Adenomatous polyposis coli protein

Gene Full Name: APC regulator of Wnt signaling pathway

Synonyms: adenomatous polyposis coli; APC; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5; DP3; GS; Protein APC