ANPEP Monoclonal Antibody

SKU: BT-MCA2504

Size:100μL

Background:Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

Research_area:Immunology

Target_protein:ANPEP

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:1C7D7

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ANPEP

Immunogen:Purified recombinant fragment of human ANPEP (AA: Extra(781-967)) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):110kDa

UniProt accession:P15144

Synonyms:APN, CD13, LAP1, P150, PEPN, GP150

GeneID:290