ALPL Polyclonal Antibody

SKU: E-AB-70384

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:ALPL

Target Synonym:AKP2;Alkaline phosphatase liver/bone/kidney;Alkaline phosphatase liver/bone/kidney isozyme;Alkaline phosphatase tissue nonspecific isozyme;Alkaline phosphatase;tissue-nonspecific isozyme;Alkaline phosphomonoesterase;Alpl;AP TNAP;AP-TNAP;APTNAP;BAP;FLJ40094;FLJ93059;Glycerophosphatase;HOPS;Liver/bone/kidney type alkaline phosphatase;MGC161443;MGC167935;PHOA;PPBT;Tissue non specific alkaline phosphatase;Tissue nonspecific ALP;TNAP;TNSALP

Research Areas:Cancer;Cell Biology;Tags and Cell Markers

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P05186,P09242,P08289

Accession:

Background:There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Concentration:200 μg/mL

Immunogen:Recombinant protein corresponding to Mouse Alkaline Phosphatase

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:WB 1:500-1:2000

Calculated MW:57kDa

ObservedMW:55kDa