AIRE Antibody, Biotin conjugated - Cat. #: CSB-PA001502HD01HU

SKU: CSB-PA001502HD01HU

Size :50ug

Clone Number:

Aliases:AIRE antibody; AIRE_HUMAN antibody; AIRE1 antibody; APECED antibody; APECED protein antibody; APS1 antibody; APSI antibody; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody; Autoimmune regulator antibody; Autoimmune regulator protein antibody; PGA1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43918

Immunogen:Recombinant Human Autoimmune regulator protein (39-108AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5\'-. ATTGGTTA-3\' combined with a 5\'-TTATTA-3\' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at \'Lys-4\', not phosphorylated at \'Thr-3\' and not methylated at \'Arg-2\'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:AIRE

Research Areas:Epigenetics and Nuclear Signaling; Immunology