Adenylosuccinate lyase antibody , Cat. # FNab00161

SKU: FNab00161

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:ADSL(adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate(PMID:18524658). Defects in ADSL are the cause of adenylosuccinase deficiency(ADSL deficiency). In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features(PMID:20884265)..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation(PMID:9545543). It has 2 isoforms produced by alternative splicing.

Immunogen:adenylosuccinate lyase

Synonyms:Adenylosuccinase, adenylosuccinate lyase, ADSL, AMPS, ASASE, ASL

Observed MW:55 kDa

Uniprot ID:P30566

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC, IF, FC

Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100

Gene ID:158

Research Area:Metabolism