ACO1 Antibody - Cat. #: CSB-PA223057

SKU: CSB-PA223057

Size :50ul

Clone Number:

Aliases:ACO 1 antibody; ACO1 antibody; ACOC_HUMAN antibody; Aconitase 1 soluble antibody; Aconitase antibody; Aconitase1 antibody; Aconitate hydratase antibody; ACONS antibody; Citrate hydro lyase antibody; Citrate hydro-lyase antibody; Cytoplasmic aconitate hydratase antibody; Ferritin repressor protein antibody; IRE BP 1 antibody; IRE-BP 1 antibody; IREB 1 antibody; IREB1 antibody; IREBP antibody; IREBP1 antibody; Iron regulatory protein 1 antibody; Iron responsive element binding protein 1 antibody; Iron-responsive element-binding protein 1 antibody; IRP 1 antibody; IRP1 antibody; OTTHUMP00000045233 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P21399

Immunogen:Synthetic peptide of Human ACO1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; ELISA:1:2000-1:10000, WB:1:1000-1:5000

Background:Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ACO1

Research Areas:Epigenetics and Nuclear Signaling;Cancer?Cardiovascular;Metabolism;Signal transduction