a-actinin (4A12) Mouse mAb

SKU: EM1261

Size: 100μL

Source:Mouse

Applications:IHC

Reactivity:Human, Rat, Mouse

Dilution:IHC 1:100-200

Immunogen:Recombinant Protein

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):103kDa

Human_gene_id:87

Human_swiss_prot_no:P12814

Subcellular_location:Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Other_name:actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody

Background:α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.