53BP1 (phospho-Ser1778) rabbit pAb

SKU: ES18530

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Rat;Mouse;

Dilution:WB 1:1000-2000

Immunogen:Synthesized phosho peptide around human 53BP1 (Ser1778)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):213kD

Human_gene_id:7158

Human_swiss_prot_no:Q12888

Subcellular_location:Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). .

Other_name:Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)

Background: