3HAO Polyclonal Antibody

SKU: BT-AP08399

Size:100μL

Background:3-Hydroxyanthranilate 3|4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs| such as liver and kidney| and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

Research_area:Metabolism; Neuroscience; Signal transduction

Target_protein:HAAO

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:3-hydroxyanthranilate 3|4-dioxygenase

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: P46952; Mouse: Q78JT3; Rat: P46953

Synonyms:3-hydroxyanthranilate 3; 4-dioxygenase (EC 1.13.11.6;3-hydroxyanthranilate oxygenase;3-HAO;3-hydroxyanthranilic acid dioxygenase;HAD)

GeneID:Human: 23498