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Updated Date: Stock Protein updated on 20171018
Research areas: Immunology
Target / Protein: hamp
Biologically active: Not Tested
Expression system: E.coli
Species of origin: Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea)
Delivery time: 3-7 business days
Uniprot ID: A1Z0M0
AA Sequence: RCRFCCRCCPRMRGCGICCRF
Tag info: NO-tagged
Expression Region: 65-85aa
Protein length: Full Length of Mature Protein
MW: 2.5 kDa
Relevance: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages Has very strong antibacterial activity against the marine Gram-negative bacteria V.alginolyticus (MIC=24 µM), V.fluvialis, V.harveyis (MIC=12 µM) and V.parahaemolyticus (MIC=6 µM). Has antibacterial activity against the Gram-negative bacteria A.hydrophila (MIC=6 µM), E.coli (MIC=24 µM), and E.coli BL21(DE3)plysS (MIC=6 µM), and the Gram-positive bacteria B.cereus (MIC=24 µM), B.subtilis (MIC=6 µM), C.glutamicum (MIC=3 µM), M.luteus (MIC=3 µM), M.lysodeikticus, S.aureus (MIC=6 µM) and S.epidermis (MIC=12 µM). Possesses antifungal activity against A.niger (MIC=24 µM), F.graminearum (MIC24 µM) and F.solani (MIC=24 µM), but lacks antifungal activity against the yeasts P.pastoris GS115 and C.albicans.
Reference: "Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea." Zhang J., Yan Q., Ji R., Zou W., Guo G. Fish Shellfish Immunol. 26:864-870(2009)
Purity: Greater than 90% as determined by SDS-PAGE.
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.