PDK1 antibody , Cat. # FNab06275

SKU: FNab06275

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Immunogen:pyruvate dehydrogenase kinase, isozyme 1

Synonyms:PDH kinase 1, PDHK1, PDK1, Pyruvate dehydrogenase kinase isoform 1

Observed MW:50kd

Uniprot ID:Q15118

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, WB, IP

Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:500

Gene ID:5163

Research Area:Signal Transduction, Metabolism