WWP1 antibody , Cat. # FNab09534

SKU: FNab09534

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Immunogen:WW domain containing E3 ubiquitin protein ligase 1

Synonyms:AIP5, DKFZp434D2111, hSDRP1, Tiul1, WW domain containing protein 1, WWP1

Observed MW:95 kDa

Uniprot ID:Q9H0M0

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IP, IHC, IF

Recommended dilution:WB: 1:200-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

Gene ID:11059

Research Area:Epigenetics, Signal Transduction, Metabolism