WNK2 Antibody, FITC conjugated - Cat. #: CSB-PA896509LC01HU

SKU: CSB-PA896509LC01HU

Size :50ug

Clone Number:

Aliases:WNK2 antibody; KIAA1760 antibody; PRKWNK2 antibody; SDCCAG43 antibody; P/OKcl.13 antibody; Serine/threonine-protein kinase WNK2 antibody; EC 2.7.11.1 antibody; Antigen NY-CO-43 antibody; Protein kinase lysine-deficient 2 antibody; Protein kinase with no lysine 2 antibody; Serologically defined colon cancer antigen 43 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y3S1

Immunogen:Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:WNK2

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Signal transduction