VPS4B antibody , Cat. # FNab09446

SKU: FNab09446

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).

Immunogen:vacuolar protein sorting 4 homolog B(S. cerevisiae)

Synonyms:MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B

Observed MW:50 kDa

Uniprot ID:O75351

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IF, IP

Recommended dilution:WB: 1:500-1:5000?IP: 1:500-1:5000?IF: 1:10-1:100

Gene ID:9525

Research Area:Metabolism